pentobarbital will reduce the extent or effect of abemaciclib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with robust CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.In decades earlier, barbiturates have been a standard part of common anest